Chemotherapy Drugs

Camptothecin-11 ( CPT11)
Irinotecan
Drug type: Irinotecan is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. This medication is classified as a "plant alkaloid" and "topoisomerase I inhibitor
read more at http://www.chemocare.com/bio/camptothecin.asp

What this drug is used for:
Metastatic colon or rectal cancer
This medication is given by infusion through a vein (intravenously, IV).

Irinotecan belongs to a class of chemotherapy drugs called plant alkaloids. Plant alkaloids are made from plants. The vinca alkaloids are made from the periwinkle plant (catharanthus rosea). The taxanes are made from the bark of the Pacific Yew tree (taxus). The vinca alkaloids and taxanes are also known as antimicrotubule agents. The podophyllotoxins are derived from the May apple plant. Camptothecan analogs are derived from the Asian "Happy Tree" (Camptotheca acuminata). Podophyllotoxins and camptothecan analogs are also known as topoisomerase inhibitors. The plant alkaloids are cell-cycle specific. This means they attack the cells during various phases of division.
Topoisomerase inhibitors (such as ironotecan) are drugs that interfere with the action of topoisomerase enzymes (topoisomerase I and II). Topoisomerase enzymes control the manipulation of the structure of DNA necessary for replication.


XELODA
Treatment of Advanced Breast and Colorectal Cancers

In patients with Colorectal Cancer, XELODA (capecitabine) is used to treat
Dukes' C (Stage III) colon cancer after surgery (called "adjuvant therapy")
Cancer of the colon or rectum (colorectal cancer) that has spread to other parts of the body. This is called metastatic colorectal cancer. You should know that in studies other medicines showed improved survival when they were taken together with 5-FU and leucovorin. In studies with XELODA, XELODA was no worse than 5-FU and leucovorin taken together. But it did not improve survival compared to these 2 medicines.

How XELODA (capecitabine) WorksThe generic name for XELODA is capecitabine ("CAPE-site-ah-bean"). XELODA is a medicine you take by mouth (orally). XELODA is changed in the body to a substance called 5-fluorouracil (5-FU). In some patients with colon, rectum, or breast cancer, 5-FU stops cancer cells from growing and decreases the size of the tumor.

XELODA is a drug taken by mouth (orally) and then converted by your body into an effective anti-cancer drug. Here's what happens after you swallow a XELODA Tablet:
XELODA travels through the digestive system into the bloodstream.
XELODA reaches the site of the cancerous cells.
Your body produces a naturally-occurring enzyme called thymidine phosphorylase, or TP. But cancerous cells have higher levels of TP than healthy cells do.
Inside the tumor XELODA is transformed into 5-FU—an effective cancer-fighting drug

read more here http://www.xeloda.com/default.aspx

Colon operation

visited Dr Khoo, Dr Wong, Dr Tan after lunar new year.
Dr Khoo sheduled a colonscope with Dr Chan on Saturday after seeing the pathology report on the wash sample from HSA in accordance to non small cell lung cancer.

The colonscope met with an obstruction and Dr Chan decided to operate on the evening.

father was warded for a week before returning home.

he plan to visit HSA on 24 Feb 2009 and Dr Khoo and Dr Chan on Sat at Gleneagle.

adenocarcinoma was report in Histology.

PET CT scan

after visit Dr Khoo, went of the PET CT Scan the next day.

http://picasaweb.google.com/ngengjin/PETCTScan?authkey=iOwjGntV3iE#

CT scan

waited for a week after bronchoscope performed by Dr Aliza http://hsajb.moh.gov.my/modules/xt_conteudo/print.php?id=35, decided to go for a

CT scan
http://picasaweb.google.com/ngengjin/CTScan

and we visited Dr Khoo Kei Siong http://www.parkwayhealth.com/Healthcare/ClinicalProgrammes/Oncology/DoctorList.asp.

Articles on Lung Cancer

you may want to read up these articles http://en.wikipedia.org/wiki/Lung_cancer, especially on diagnosis!!, http://www.ncbi.nlm.nih.gov/pubmed/194691, the higher dose chemotherapy which might prolong life, and the article in mandarin http://zh.wikipedia.org/wiki/%E8%82%BA%E7%99%8C . or my blogs on it

Cancerhttp://apcancel.blogspot.com/Lung Cancerhttp://aplungcancer.blogspot.com/tradition and/or complimentary medicineshttp://tcmedicine.blogspot.com/

Lung bronchoscope

done on the 13th Jan 2009, with one wash sample and two cut samples.

on the 26th Dec 2009 visited Hospital Sultanah Aminah (HSA) respiratory unit to assign a appointment on next coming tuesday.

on the appointment day, blood sample, and few days phelgm were taken for testing, and phelgm cultural was developed for two months, and appointment for colonscope was schedule on the 2th Feb 2009.

next tuesday blood sample and phelgm does not indicate any infection, and the above bronchurescope was shedule on the 13th Jan 2009.

on the 12th Jan Dec, father was preward for check up, both blood, E.C.G all within accept range.

on the report received two weeks later on the wash sample, show that the pathologist confirm non small cell lung cancer on the 14th Jan 2009. and adenocarcinoma in the histology report received on the 24th Feb 2009.

x-ray of left lung 左肺 X -射线片

side view of left lung 左肺側面观


















左肺正面观

front view of left lung

在08年12月20号, 父亲的生日晚餐后, 父亲发现，他的痰表面载血。
在08年12月24日，圣诞节前夕，在他的侄儿的家，参加了烧烤后，他再次发现他痰表面载血。
在2008年12月26日，他访问他的表弟和做上述X射线.

on father's birthday the 20th Dec 2008, after a porriage dinner and cendol dessert, father found that his phlegm surface contained blood.

on the 24th Dec 2008, christmas eve, after attending a barbecue at his nephew's house, again he discovered his phlegm surface contained blood.

on the 26th Dec 2008, boxing day, he visit his cousin and done the above x-ray.